BDNF, also commonly known as Brain-derived Neurotrophic Factor, is a protein found in humans encoded by BDNF Gene. It belongs to the neurotrophin family and is closely related to CNGF or a canonical nerve growth factor. It is generally found in the peripheral region and in the nervous system.
BDNF is active in several vital parts of the nervous system like the cortex, hippocampus and basal forebrain. It is also found in saliva, kidney, skeletal muscle, motor neurons and retina. BDNF level can be increased by performing several physical exercises. In neurobiology, BDNF plays a vital role in metabolism. BDNF is one of the significant factors employed in neuron maintenance and synaptic plasticity; it helps treat depression.
This BDNF binds two receptors TrkB and LNGFR on the surface, making it possible to respond to growth factors. It may also regulate the activities of several neurotransmitters, which includes Apha-7 nicotonic receptor.
A gene obtains BDNF also called BDNF and it is found in the chromosome in humans. Eight different promoters contribute to the transcription of BDNF. With the help of multiple neural activities, BDNF can increase. BDNF consists of numerous known SNP (single nucleotide polymorphism).
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