Drugs that should not be taken with CBD

Drugs that should not be taken with CBD

Drugs that should not be taken with CBD

The usage of CBD is becoming increasingly popular around the world. However, with recent revelations, it has become evident that CBD may react adversely with certain medications to produce adverse side effects. Therefore, it is best to know about CBD wellness.

Does CBD oil also react with the medication that I’m taking?

CBD might interfere with many drugs’ ability to metabolize other drugs in the body. When an individual consumes CBD in any form, it essentially inhibits the system’s ability to metabolize certain compounds that form an essential part of the medication that the person is already taking. Since CBD might react with most of these compounds and several of these compounds form necessary and crucial medicines, this phenomenon can pose several risks. Although CBD has been used for ages for the treatment of various health issues, these risks might be particularly harmful to you if you are consuming powerful painkillers like oxycodone and fentanyl.

The Cytochrome P450 System

The Cytochrome P450 System found in the liver consists of enzymes that process and eliminates potentially toxic compounds. The P450 enzyme system is primarily responsible for metabolizing over 60% of all prescription pharmaceuticals.

CBD and CYP3A4 Enzyme

It is important to note that CBD does not go ahead and react with every drug and painkiller out there. That is just a myth. Certain medications contain selected compounds that are susceptible to be attacked by the CBD molecules and that cannot be metabolized by the system efficiently. That being said, most CBD interactions may take place over a specific CYP enzyme called CYP3A4. The way CYP3A4 metabolizes CBD may vary significantly from one person to another as a result of variations in our DNA makeup.

In addition to cannabidiol, drugs metabolized by CYP3A4 include:

  • Claritin
  • Prednisone
  • Fentanyl
  • Viagra
  • Cialis
  • Ambien
  • Topamax
  • Xanax
  • Lipitor

If you are taking any of the drugs mentioned above, consult with a doctor before introducing CBD products to your daily regimen.

Interactions with CBD and CYP2C19

CBD inhibits CYP2C19 enzymes in the cytochrome P450 complex. This enzyme is primarily responsible for metabolizing many proton pump inhibitors and antiepileptic drugs such as risperidone, pantoprazole, and clobazam. Taking very high and regular doses of CBD may interfere with the degradation and metabolization of these drugs leading to their increased bioavailability.

This was shown in a two-month-long clinical study where patients were treated for epilepsy with clobazam and CBD. The CBD drug interaction with CYP3A4 and CYP2C19 may lead to increased clobazam bioavailability. Researchers believe this same phenomenon might occur when taking other drugs that are metabolized by CYP2C19 enzymes.

If you are currently taking any medication, we encourage you to consult with a doctor before beginning a CBD regimen. Medical professionals have a knack for figuring out what compounds go in what drugs and whether any of the other compounds present in your prescribed medication might react adversely with your CBD oil or tablet regimen.

Blood thinners

If you are thinking of starting a CBD regimen along with your medication, you should pay particular attention to blood thinner medications like warfarin. Mixing CBD with blood thinners might make the blood thinner stay in your system for too long without being broken down, increasing the risk of potentially harmful side effects. This is one of the most critical effects of CBD with blood-thinning medication. Any drug that has gets metabolized by the Cytochrome P450 system may interact heavily with CBD. Some examples are:

  • Steroids
  • HMG CoA reductase inhibitors
  • Calcium channel blockers
  • Antihistamines
  • Prokinetics
  • HIV antivirals
  • Immune modulators
  • Benzodiazepines
  • Antiarrhythmics
  • Antibiotics
  • Anesthetics
  • Antipsychotics
  • Antidepressants
  • Anti-epileptics
  • Beta-blockers
  • PPIs
  • NSAIDs
  • Angiotensin II blockers
  • Oral hypoglycemic agents
  • Sulfonylureas


We believe that for the most effective and safest CBD consumption practices, you must use pharmacist formulated CBD from a trusted CBD manufacturer and consult with your physician if you are taking any other medications. Using high-quality CBD with professional guidance may help you make the most of your CBD routine and ensure that you are not a victim of undesirable side effects!

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